Nabta Editorial Team • November 21, 2024 • 5 min read
Metformin is a drug used for the treatment of Type 2 Diabetes and insulin-resistant PCOS (Polycystic Ovaries Syndrome).
Metformin works by decreasing the production of glucose (sugar) by the liver and increasing the insulin sensitivity of body tissues. This means that more glucose is absorbed by cells in the body and converted into energy, and the amount of insulin in the blood is also reduced.
Metformin is sometimes prescribed to women with PCOS to regulate menstrual cycles as it has been shown to lower levels of testosterone and other androgen hormones (which are the primary causes of PCOS).
There is no research to support the use of metformin to facilitate weight loss. Women suffering from insulin resistance may experience weight loss when taking metformin as a result of their bodies being better able to process glucose.
UK and international clinical guidelines do not recommend metformin as a first-line treatment, if at all, except in cases of extreme insulin resistance. Recommended treatment options include lifestyle modifications independent of medication, or clomiphene as a drug-based alternative.
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