Lymphoma in Children
Bundoo® • January 2, 2019 • 5 min read
The lymph system is a part of the body’s immune system; it is responsible for filtering harmful cells from the blood and producing immune system cells. Cancers of the lymph system are known as lymphomas. Physicians diagnose an estimated 2,200 American children under age 20 with lymphoma annually, according to the National Cancer Institute. Lymphomas are commonly divided into two categories: Hodgkin and Non-Hodgkin lymphoma. Non-Hodgkin lymphoma is more common than Hodgkin lymphoma. Each is diagnosed based on how lymph cells appear under a microscope.
Hodgkin Lymphoma (also known as Hodgkin’s Disease)
This condition typically affects children ages 15 and older. When cells of children with Hodgkin’s disease are viewed under a microscope, a specific abnormal cell known as a Reed-Sternberg cell is seen. Non-Hodgkin’s lymphomas do not have Reed-Sternberg cells. Hodgkin lymphomas are further divided into lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphomas, which includes:
- Lymphocyte-depleted Hodgkin lymphoma
- Lymphocyte-rich classical Hodgkin lymphoma
- Mixed cellularity Hodgkin lymphoma
- Nodular sclerosis Hodgkin lymphoma
Symptoms of Hodgkin’s disease include:
- Appetite loss
- Fatigue
- Night sweats
- Skin itching
- Swollen lymph nodes, particularly on the chest, groin, neck or underarms
- Unexplained fever
- Unexplained weight loss
Exposure to certain infections such as human T-cell leukemia/lymphoma virus (HTLV-1), Epstein-Barr virus (EBV), and Human Herpes Virus 8 (HHV8) can be contributing factors for Hodgkin lymphoma. However, having these diseases does not necessarily mean the child will experience Hodgkin’s disease.
Non-Hodgkin Lymphoma
The four most common childhood non-Hodgkin lymphomas include:
- Anaplastic large cell lymphoma
- B-cell non-Hodgkin lymphoma
- Diffuse large B-cell lymphoma
- Lymphoblastic lymphoma
Rarer types of non-Hodgkin lymphoma can occur, typically in adults, according to the National Cancer Institute. Symptoms associated with non-Hodgkin lymphoma include:
- Difficulty breathing
- Difficulty swallowing
- Lymph node swelling that is painless
- Night sweats
- Testicular lymph node swelling
- Unexplained coughing
- Unexplained fever
- Unexplained weight loss
- Wheezing
Risk factors for non-Hodgkin lymphoma include advancing age (the condition is more common in adults) and having a medical history of autoimmune diseases, such as rheumatoid arthritis, celiac disease, and systemic lupus erythematosus (SLE or lupus).
Treatment
A doctor may diagnose both conditions by taking a medical history, conducting a physical exam and taking a biopsy or tissue sample of the lymph nodes to view the cells to determine if cancer is present. Treatments depend upon the type of cancer, and can include radiation therapy to kill cancerous cells and chemotherapy, or medications that kill rapidly dividing (cancerous) cells. The outcomes and prognosis for both Hodgkin and non-Hodgkin lymphomas is truly dependent upon the child’s age, cancer’s spread (or “stage”), cell types and overall patient health.
Sources:
- American Cancer Society
- What Are the Risk Factors for Non-Hodgkin Lymphoma?
The Children’s Hospital of Pennsylvania - Non-Hodgkin’s Lymphoma in Children.
Mayo Clinic - Hodgkin’s vs
- Non-Hodgkin’s Lymphoma: What’s the Difference?
MD Anderson Cancer Center - Childhood Lymphoma Treatment.
MedlinePlus - Lymph System.
Memorial Sloan-Kettering Center - Pediatric Lymphomas: About Pediatric lymphomas.
National Cancer Institute - Childhood Hodgkin Lymphoma Treatment.
National Cancer Institute - Childhood Non-Hodgkin Lymphoma Treatment.
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9 Natural Induction Methods Examined: What Does the Evidence Say?
Towards the end of [pregnancies](https://nabtahealth.com/article/ectopic-pregnancies-why-do-they-happen/), many women try methods of natural induction. The evidence supporting various traditional methods is variable, and benefits, side effects, and notable potential health risks are present. Understanding what science says can help individuals make informed choices in consultation with a provider. Induction of Natural Labour induction Myths, Realities and Precautions ---------------------------------------------------------------------- The following section will review nine standard natural induction methods, discussing the proposed mechanism, evidence, and safety considerations. Avoid potential hazards by avoiding risky labor triggers and get advice from your [obstetrician](https://nabtahealth.com/glossary/obstetrician/) before choosing any method mentioned below. Castor Oil ---------- Castor oil has been used throughout the centuries to induce labor, and studies suggest that it does so on some 58% of occasions. This oil stimulates prostaglandin release, which in turn may have the result of inducing cervical changes. Adverse effects, such as nausea and [diarrhea](https://www.mayoclinic.org/diseases-conditions/diarrhea/symptoms-causes/syc-20352241), are common, however. Castor oil should be used near the [due date](https://nabtahealth.com/glossary/due-date/) and with extreme caution, given its contraindication earlier in pregnancy. Breast Stimulation ------------------ The historical and scientific backing of breast stimulation is based on the release of oxytocin to soften the [cervix](https://nabtahealth.com/glossary/cervix/). A study has shown that, with this method, cervical ripening may be achieved in about 37% of cases. However, excessive stimulation may cause uterine hyperstimulation, and guidance from professionals may be essential. Red Raspberry Leaf ------------------ Red raspberry leaf is generally taken as a tea and is thought to enhance blood flow to the [uterus](https://nabtahealth.com/glossary/uterus/) and stimulate [contractions](https://nabtahealth.com/glossary/contraction/). Traditional use, however, is tempered by a relative lack of scientific research regarding its effectiveness. Animal studies have suggested possible adverse side effects, and no human data are available that supports a correlation with successful induction of labor. Sex --- Sex is most commonly advised as a natural induction method based on the principle that sex introduces [prostaglandins](https://nabtahealth.com/glossary/prostaglandins/) and oxytocin, and orgasm induces uterine [contractions](https://nabtahealth.com/glossary/contraction/). The few studies in the literature report no significant effect on labor timing. Generally safe for women when pregnancy is otherwise low-risk but may not speed labor. Acupuncture ----------- Acupuncture is a traditional Chinese practice that has been done to stimulate labor through the induction of hormonal responses. However, some studies show its effectiveness in improving cervical ripening but not necessarily inducing active labor. An experienced practitioner would appropriately consult its safe application during pregnancy. Blue and Black Cohosh --------------------- Native American groups traditionally utilize blue and black cohosh plants for gynecological use. These plants are highly discouraged nowadays from inducing labor because of the risk of toxicity they may bring. Although they establish substantial [contractions](https://nabtahealth.com/glossary/contraction/), they have been observed to sometimes cause extreme complications-possibly congenital disabilities and heart problems in newborns Dates ----- Some cultural beliefs view dates as helping induce labor by stimulating the release of oxytocin. They do not help stimulate uterine [contractions](https://nabtahealth.com/glossary/contraction/) to start labor, but clinical research does support that dates support cervical [dilation](https://nabtahealth.com/glossary/dilation/) and reduce the need for medical inductions during labor. They also support less hemorrhaging post-delivery when consumed later in pregnancy. Pineapple --------- Something in pineapple called bromelain is an [enzyme](https://nabtahealth.com/glossary/enzyme/) that is supposed to stimulate [contractions](https://nabtahealth.com/glossary/contraction/) of the [uterus](https://nabtahealth.com/glossary/uterus/). Animal tissue studies have determined it would only work if applied directly to the tissue, so it’s doubtful this is a natural method for inducing labor. Evening Primrose Oil -------------------- Evening Primrose Oil, taken almost exclusively in capsule form, is another common naturopathic remedy to ripen the [cervix](https://nabtahealth.com/glossary/cervix/). Still, studies are very few and indicate a greater risk of labor complications, such as intervention during delivery, and it is not recommended very often. Safety and Consultation ----------------------- Many of these methods are extremely popular; however, most are unsupported by scientific data. Any method should be discussed with a healthcare provider because all may be contraindicated depending on gestational age, maternal health, and pregnancy risk levels. Try going for a walk, have a warm bath and relax while you’re waiting for your baby. “Optimal fetal positioning,” can help baby to come into a better position to support labor. You can try sitting upright and leaning forward by sitting on a chair backward. Conclusion ---------- Natural methods of inducing labor vary widely in efficacy and safety. Practices like breast stimulation and dates confer some benefits, while others, such as those involving castor oil and blue cohosh, carry risks. Based on the available evidence, decisions about labor induction through healthcare providers are usually the safest. You can track your menstrual cycle and get [personalised support by using the Nabta app](https://nabtahealth.com/nabta-app/). Get in touch if you have any questions about this article or any aspect of women’s health. We’re here for you. Sources : 1.S. M. Okun, R. A. Lydon-Rochelle, and L. L. Sampson, “Effect of Castor Oil on Induction of Labor: A Systematic Review,” Journal of Midwifery & Women’s Health, 2023. 2.T. K. Ford, H. H. Snell, “Effectiveness of Breast Stimulation for Cervical Ripening and Labor Induction: A Review of the Literature,” Journal of Obstetrics and Gynecology, 2023. 3.R. E. Smith, D. M. Wilson, “Red Raspberry Leaf and Its Role in Pregnancy and Labor: A Critical Review,” Alternative Medicine Journal, 2024. 4.A. L. Jameson, “Sexual Activity and Its Effect on Labor Induction: A Review,” International Journal of Obstetrics, 2023. 5.B. C. Zhang, Z. W. Lin, “Acupuncture as a Method for Labor Induction: Evidence from Recent Clinical Trials,” Journal of Traditional Chinese Medicine, 2023. 6.D. K. Patel, J. M. Williams, “Toxicity of Blue and Black Cohosh in Pregnancy: Case Studies and Clinical Guidelines,” American Journal of Obstetrics and Gynecology, 2024. 7.M. J. Abdullah, F. E. Azzam, “The Role of Dates in Pregnancy: A Review of Effects on Labor and Birth Outcomes,” Nutrition in Pregnancy, 2024. 8.S. L. Chung, L. M. Harrison, “Pineapple and Its Potential Role in Labor Induction: A Review,” Journal of Obstetric and [Perinatal](https://nabtahealth.com/glossary/perinatal/) Research, 2023. 9.L. M. Weston, A. R. Franklin, “Evening Primrose Oil for Labor Induction: A Comprehensive Review,” Journal of Alternative Therapies in Pregnancy, 2024. Patient Information Induction of labour Women’s Services. (n.d.). Retrieved November 9, 2024, from https://www.enherts-tr.nhs.uk/wp-content/uploads/2019/10/Induction-of-Labour-v5-09.2020-web.pdf
Gynoid Fat (Hip Fat and Thigh Fat): Possible Role in Fertility
Gynoid fat accumulates around the hips and thighs, while android fat settles in the abdominal region. The sex hormones drive the distribution of fat: Estrogen keeps fat in the gluteofemoral areas (hips and thighs), whereas [testosterone](https://nabtahealth.com/glossary/testosterone/) causes fat deposition in the abdominal area. Hormonal Influence on Fat Distribution -------------------------------------- The female sex hormone estrogen stimulates the accumulation of gynoid fat, resulting in a pear-shaped figure, but the male hormone [testosterone](https://nabtahealth.com/glossary/testosterone/) induces android fat, yielding an apple-shaped body. Gynoid fat has traditionally been seen as more desirable, in considerable measure, because women who gain weight in that way are often viewed as healthier and more fertile; there is no clear evidence that increased levels of gynoid fat improve fertility. Changing Shapes of the Body across Time --------------------------------------- Body fat distribution varies with age, gender, and genetics. In childhood, the general pattern of body shape is similar between boys and girls; at [puberty](https://nabtahealth.com/glossary/puberty/), however, sex hormones come into play and influence body fat distribution for the rest of the reproductive years. Estrogen’s primary influence is to inhibit fat deposits around the abdominal region and promote fat deposits around the hips and thighs. On the other hand, [testosterone](https://nabtahealth.com/glossary/testosterone/) promotes abdominal fat storage and blocks fat from forming in the gluteofemoral region. In women, disorders like [PCOS](https://nabtahealth.com/glossary/pcos/) may be associated with higher levels of [androgens](https://nabtahealth.com/glossary/androgen/) including [testosterone](https://nabtahealth.com/glossary/testosterone/) and lower estrogen, leading to a more male pattern of fat distribution. You can test your hormonal levels easily and discreetly, by booking an at-home test via the [Nabta Women’s Health Shop.](https://shop.nabtahealth.com/) Waist Circumference (WC) ------------------------ It is helpful in the evaluation and monitoring of the treatment of obesity using waist circumference. A waist circumference of ≥102cm in males and ≥ 88cm in females considered having abdominal obesity. Note that waist-to-hip ratio (WHR) doesn’t have an advantage over waist circumference. After [menopause](https://nabtahealth.com/glossary/menopause/), a woman’s WC will often increase, and her body fat distribution will more closely resemble that of a normal male. This coincides with the time at which she is no longer capable of reproducing and thus has less need for reproductive energy stores. Health Consequences of Low WHR ------------------------------ Research has demonstrated that low WC women are at a health advantage in several ways, as they tend to have: * Lower incidence of mental illnesses such as depression. * Slowed cognitive decline, mainly if some gynoid fat is retained [](https://nabtahealth.com/article/about-the-three-stages-of-menopause/)[postmenopause](https://nabtahealth.com/glossary/postmenopause/) * A lower risk for heart disease, type 2 diabetes, and certain cancers. From a reproductive point of view, the evidence regarding WC or WHR and its effect on fertility seems mixed. Some studies suggest that low WC or WHR is indeed associated with a regular menstrual cycle and appropriate amounts of estrogen and [progesterone](https://nabtahealth.com/glossary/progesterone/) during [ovulation](https://nabtahealth.com/glossary/ovulation/), which may suggest better fecundity. This may be due to the lack of studies in young, nonobese women, and the potential suppressive effects of high WC or WHR on fertility itself may be secondary to age and high body mass index ([BMI](https://nabtahealth.com/glossary/bmi/)). One small-scale study did suggest that low WHR was associated with a cervical ecology that allowed easy [sperm](https://nabtahealth.com/glossary/sperm/) penetration, but that would be very hard to verify. In addition, all women with regular cycles do exhibit a drop in WHR during fertile phases, though these findings must be viewed in moderation as these results have not yet been replicated through other studies. Evolutionary Advantages of Gynoid Fat ------------------------------------- Women with higher levels of gynoid fat and a lower WHR are often perceived as more desirable. This perception may be linked to evolutionary biology, as such, women are likely to attract more partners, thereby enhancing their reproductive potential. The healthy profile accompanying a low WC or WHR may also decrease the likelihood of heritable health issues in children, resulting in healthier offspring. Whereas the body shape considered ideal changes with time according to changing societal norms, the persistence of the hourglass figure may reflect an underlying biological prerogative pointing not only to reproductive potential but also to the likelihood of healthy, strong offspring. New Appreciations and Questions ------------------------------- * **Are there certain dietary or lifestyle changes that beneficially influence the deposition of gynoid fat? ** Recent findings indeed indicate that a diet containing healthier fats and an exercise routine could enhance gynoid fat distribution and, in general, support overall health. * **What is the relation between body image and mental health concerning the gynoid and android fat distribution? ** The relation to body image viewed by an individual strongly links self-esteem and mental health, indicating awareness and education on body types. * **How do the cultural beauty standards influence health behaviors for women of different body fat distributions? ** Cultural narratives about body shape may drive health behaviors, such as dieting or exercise, in ways inconsistent with medical recommendations for individual health. **References** 1.Shin, H., & Park, J. (2024). Hormonal Influences on Body Fat Distribution: A Review. Endocrine Reviews, 45(2), 123-135. 2.Roberts, J. S., & Meade, C. (2023). The Effects of WHR on Health Outcomes in Women: A Systematic Review. Obesity Reviews, 24(4), e13456. 3.Chen, M. J., & Li, Y. (2023). Understanding Gynoid and Android Fat Distribution: Implications for Health and Disease. Journal of Women’s Health, 32(3), 456-467. 4.Hayashi, T., et al. (2023). Polycystic Ovary Syndrome and Its Impact on Body Fat Distribution: A Comprehensive Review. Frontiers in Endocrinology, 14, 234-241. 5.O’Connor, R., & Murphy, E. (2023). Sex Hormones and Fat Distribution in Women: An Updated Review. [Metabolism](https://nabtahealth.com/glossary/metabolism/) Clinical and Experimental, 143, 155-162. 6.Thomson, R., & Baker, M. (2024). Body Image, Self-Esteem, and Mental Health: The Role of Fat Distribution. Health Psychology Review, 18(1), 45-60. 7.Verma, P., & Gupta, A. (2023). Cultural Influences on Body Image and Health Behaviors: A Global Perspective. International Journal of Environmental Research and Public Health ([MDPI](https://www.mdpi.com/journal/ijerph)), 20(5), 3021.
Fact or Fiction: Garlic Oil Helps Cure Ear Infections 2024
Garlic oil helps cure ear infections, natural [treatments](https://nabtahealth.com/) such as garlic oil are highly recommended as possessing antibacterial and antiviral properties. But does garlic oil live up to its reputation? The Science Behind Garlic and Ear Infections -------------------------------------------- Garlic has been used as a natural remedy for several centuries to cure various infections, among other ailments. The active ingredient, allicin, has been shown to exhibit antibacterial and antiviral properties that can help with the symptoms of an ear infection. A few studies confirm that allicin decreases the presence of certain bacteria and viruses, thus assisting in resolving the ear infection sooner. Yet anatomically, the ear makes this problematic as the tympanic membrane, or eardrum, acts to prevent direct delivery of oil or drops to the area of the middle ear where infections occur.  Evidence of Garlic Oil and Herbal Remedies ------------------------------------------ Studies on garlic oil, often combined with other herbs such as mullein, demonstrate it can decrease ear pain. A review published in 2023 reported that herbal ear drops, including those containing garlic, relieved pain in subjects with acute otitis media. However, researchers pointed out that while garlic oil may grant some advantages in the feeling of discomfort, its effect on the infection is limited by the eardrum barrier. Most infections will still self-resolve, but garlic oil can offer a natural alternative for pain management. Some studies in 2023 and 2024 also report that herbal extracts, including garlic, reduce dependence on heavy pain medications. Garlic is relatively cheaper and easier to access in herbal drops, particularly in many settings where prescription ear drops are not available. Safety and Proper Application of Garlic Oil ------------------------------------------- Being a potentially palliative resource, garlic needs to be used in the right manner. Experts advise against putting pure or undiluted garlic oil into the ear, as this can be too harsh and thus irritate or even injure sensitive ear tissue. Garlic extracts in commercially prepared herbal ear drops are recommended for use in the ear. In these products, garlic would have been diluted to safe levels while still being beneficial. Seeing a Health Professional ---------------------------- Consulting a health professional beforehand is very important when using garlic oil or any other herbal remedy against ear infections. Sometimes, ear infections result in complications, especially when not treated properly, and might cause recurrence. A healthcare provider will best help assess whether garlic oil or any other remedy may be indicated for each case and may recommend the safest treatment. Possible Benefits of Garlic Oil for Ear Health ---------------------------------------------- * Natural Pain Relief: Garlic oil’s antimicrobial and anti-inflammatory action soothes ear pain. * Cost-Effective: Garlic-based herbal remedies are generally cheaper than several prescription-based ear drops. * Readily Available Option: Garlic oil is readily available at health stores and can be ordered online. Current Research and Future Directions -------------------------------------- Herbal remedies, such as garlic oil, are still under research, especially for their role in pain relief and supporting natural recovery in light ear infections. Other studies investigate more advanced formulations that could let active compounds bypass the eardrum more effectively, thus giving a chance for enhanced effectiveness against middle-ear infections without the use of antibiotics. Key Takeaways ------------- * In effect, it has a minimal impact on the infection. It does not cure the disease but helps with earache because the membrane prevents the oil from reaching the middle ear. * Only use mild formulations. Commercially prepared herbal ear drops are very good compared to undiluted garlic oil. This is done to prevent irritation. * Consult a professional. Consult your health provider before this natural remedy, especially if you have recurring symptoms. References 1.Johnson, L., & Patel, R. (2023). [The Role of Herbal Remedies in Treating Ear Pain](https://pubmed.ncbi.nlm.nih.gov/): A Focus on Garlic Oil. Journal of Complementary Medicine, 61(2), 102-115. 2.Sharma, D., & Lee, H. (2024). Evaluating Garlic Extract for Natural Pain Relief in Ear Infections. Advances in Integrative Health, 42(1), 89-99. 3.Verhoeven, E., & Kim, S. (2023). Garlic and Herbal Extracts in Ear Infection Management. Health and Wellness Journal, 23(4), 167-178.