What is Thrombophilia?
Samantha Dumas • October 19, 2021 • 5 min read
- Thrombophilia is a condition that is either genetic or acquired.
- People with thrombophilia are at a higher risk of developing blood clots including DVT (deep vein thrombosis) and PE (pulmonary emboli)
- Pregnant women with genetic or acquired thrombophilia are at greater risk of experiencing complications including pre-term birth.
- Rare blood clots have been associated with the Oxford Astrazeneca Covid vaccine, however professionals recommend the benefits of the vaccine outweigh the risks of thrombosis.
What is thrombophiila
Thrombophilia is a medical condition where a person has an increased risk of developing dangerous blood clots in the veins or arteries.
When haemostasis, the normal clotting process in the blood, is altered it results in a person’s blood clotting more readily. This can lead to a thrombus (blood clot) forming in the blood vessels. A thrombus is a clump of blood cells (platelets, fibrin and other blood components) that attaches to the wall of a blood vessel. Sometimes part of the blood clot breaks off and travels towards the lungs with potentially serious consequences.
Deep vein thrombosis (DVT) is when a blood clot forms in a deep vein, and pulmonary embolism (PE) is when a blood clot travels through the body and gets caught in one of the pulmonary arteries in the lungs, blocking blood flow to the lungs.
When DVT and pulmonary embolism occur together it’s called venous thromboembolism (VTE).
Common causes of thrombophilia
Thrombophilia is either genetic or acquired (has no link with genes).
Genetic types of thrombophilia are “abnormalities of the genes that are responsible for making coagulation proteins” and include:
- Factor V Leiden, a mutation of the F5 gene
- Prothrombin thrombophilia, a mutation of the F2 gene
- Congenital dysfibrinogenemia, a bleeding disorder
- Hereditary antithrombin deficiency
- Heterozygous protein C deficiency
- Heterozygous protein S deficiency
Acquired thrombophilia is when non-hereditary conditions increase the risk of blood clots, such situations include:
- Antiphospholipid syndrome (APS)
- Cancer and some medications that treat cancer
- Human immunodeficiency virus (HIV)
- Prolonged bed rest following an operation, during an illness or hospital stay
- Prolonged periods of immobility during a long journey
- Obesity
- Pregnancy
- Hormone replacement therapy (HRT) and the contraceptive pill
Symptoms of thrombophilia. How do I know if I have a blood clot?
Typically, you won’t realise you have thrombophilia until you have symptoms of a blood clot. If you do experience any DVT or PE symptoms, it’s important to act quickly. The UK’s National Health Service (NHS) lists the signs to look for under urgent and emergency attention.
Signs of a DVT in your leg or other part of your body, urgent attention is needed:
- Throbbing or cramping pain in the calf or thigh of one leg
- Swelling in one leg
- Skin warm to touch or red and darkened on one leg
- Swollen, hard or sore veins
Signs of a pulmonary embolism or other serious condition, immediate emergency attention is required:
- Severe difficulty breathing
- Heart beating very fast
- Chest pain or discomfort and coughing
- A person has passed out
Will thrombophilia affect my pregnancy?
The risk of thrombophilia affecting a pregnancy is higher for women with certain types of acquired and genetic thrombophilia, with increased chance of pre-eclampsia, placental abruption, miscarriage and preterm birth.
Most women will have healthy pregnancies. However, if you are pregnant or trying to become pregnant and have genetic or acquired thrombophilia speak to your healthcare team about an appropriate plan for managing your pregnancy.
Is it safe to take HRT for menopause if I carry a risk of blood clots?
Much of what we have been told about the link between HRT and blood clots comes from dated research when the older forms of oestrogen and synthetic progesterone were widely used in HRT.
In fact, for menopausal women with an acquired or inherited clotting disorder Thrombosis UK tells us that transdermal oestrogen, absorbed through the skin, is safer for menopausal women to take than the oral oestrogen pill, as it does not cause blood changes that could increase the risk of a blood clot.
“For most women, the benefits of HRT outweigh the risks. For those at risk of a blood clot, HRT is safest when oestrogen is absorbed through the skin and micronised progesterone is used.”
Can I take the oral contraceptive pill if I have a blood clotting disorder?
Oestrogen in the combined contraceptive pill can increase the risk of a blood clot. The NHS describes this risk as “very small, but your doctor will check if you have certain risk factors before prescribing the pill.”
Is it safe to have any of the Covid vaccines if I have thrombophilia?
Jo Jerrome, chief executive of Thrombosis UK was quoted as saying: “Having a previous thrombosis or thrombophilia (sticky blood) is not a risk factor for developing the rare post-Covid-19 vaccine thrombosis and thrombocytopenia.”
Although there have been some rare blood clots associated with the Oxford AstraZeneca vaccine, the scientific advice puts the risk-benefit strongly in favour of the vaccine. Seek medical advice if you are unsure.
How is thrombophilia diagnosed?
Thrombophilia is usually diagnosed only after a blood clotting event. Blood tests will determine whether you have acquired or inherited hypercoagulable states and whether you are at risk of further clotting. You will need to wait around 6-8 weeks after a significant blood clotting event, and after you have stopped taking anticoagulant medication, before the tests can be carried out.
Can thrombophilia be treated?
The following recommendations should be provided by your healthcare team to treat blood clots resulting from thrombophilia:
- Anticoagulant medication
- Compression socks
- Regular physical activity
- Drinking lots of water
- Lifestyle changes
Depending on the severity of the clot, your healthcare team may also recommend continued anticoagulant medication and regular health check-ups.
Nabta is reshaping women’s healthcare. We support women with their personal health journeys, from everyday wellbeing to the uniquely female experiences of fertility, pregnancy, and menopause. You can track your symptoms and get personalised support by using the Nabta app.
Get in touch if you have any questions about this article or any aspect of women’s health. We’re here for you.
Sources
“Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19” Thombosis UK, https://thrombosisuk.org/covid-19-thrombosis.php
“Thrombophilia” Patient, https://patient.info/allergies-blood-immune/blood-clotting-tests/thrombophilia
“Pulmonary Embolism”, Mayo Clinic https://www.mayoclinic.org/diseases-conditions/pulmonary-[embolism](https://nabtahealth.com/glossary/embolism/)/symptoms-causes/syc-20354647
What is Thrombophilia? Vascular Cures https://vascularcures.org/thrombophilia/
“Thrombophilia”, NHS https://www.nhs.uk/conditions/thrombophilia/
Download the Nabta App
Related Articles
9 Natural Induction Methods Examined: What Does the Evidence Say?
Towards the end of [pregnancies](https://nabtahealth.com/article/ectopic-pregnancies-why-do-they-happen/), many women try methods of natural induction. The evidence supporting various traditional methods is variable, and benefits, side effects, and notable potential health risks are present. Understanding what science says can help individuals make informed choices in consultation with a provider. Induction of Natural Labour induction Myths, Realities and Precautions ---------------------------------------------------------------------- The following section will review nine standard natural induction methods, discussing the proposed mechanism, evidence, and safety considerations. Avoid potential hazards by avoiding risky labor triggers and get advice from your [obstetrician](https://nabtahealth.com/glossary/obstetrician/) before choosing any method mentioned below. Castor Oil ---------- Castor oil has been used throughout the centuries to induce labor, and studies suggest that it does so on some 58% of occasions. This oil stimulates prostaglandin release, which in turn may have the result of inducing cervical changes. Adverse effects, such as nausea and [diarrhea](https://www.mayoclinic.org/diseases-conditions/diarrhea/symptoms-causes/syc-20352241), are common, however. Castor oil should be used near the [due date](https://nabtahealth.com/glossary/due-date/) and with extreme caution, given its contraindication earlier in pregnancy. Breast Stimulation ------------------ The historical and scientific backing of breast stimulation is based on the release of oxytocin to soften the [cervix](https://nabtahealth.com/glossary/cervix/). A study has shown that, with this method, cervical ripening may be achieved in about 37% of cases. However, excessive stimulation may cause uterine hyperstimulation, and guidance from professionals may be essential. Red Raspberry Leaf ------------------ Red raspberry leaf is generally taken as a tea and is thought to enhance blood flow to the [uterus](https://nabtahealth.com/glossary/uterus/) and stimulate [contractions](https://nabtahealth.com/glossary/contraction/). Traditional use, however, is tempered by a relative lack of scientific research regarding its effectiveness. Animal studies have suggested possible adverse side effects, and no human data are available that supports a correlation with successful induction of labor. Sex --- Sex is most commonly advised as a natural induction method based on the principle that sex introduces [prostaglandins](https://nabtahealth.com/glossary/prostaglandins/) and oxytocin, and orgasm induces uterine [contractions](https://nabtahealth.com/glossary/contraction/). The few studies in the literature report no significant effect on labor timing. Generally safe for women when pregnancy is otherwise low-risk but may not speed labor. Acupuncture ----------- Acupuncture is a traditional Chinese practice that has been done to stimulate labor through the induction of hormonal responses. However, some studies show its effectiveness in improving cervical ripening but not necessarily inducing active labor. An experienced practitioner would appropriately consult its safe application during pregnancy. Blue and Black Cohosh --------------------- Native American groups traditionally utilize blue and black cohosh plants for gynecological use. These plants are highly discouraged nowadays from inducing labor because of the risk of toxicity they may bring. Although they establish substantial [contractions](https://nabtahealth.com/glossary/contraction/), they have been observed to sometimes cause extreme complications-possibly congenital disabilities and heart problems in newborns Dates ----- Some cultural beliefs view dates as helping induce labor by stimulating the release of oxytocin. They do not help stimulate uterine [contractions](https://nabtahealth.com/glossary/contraction/) to start labor, but clinical research does support that dates support cervical [dilation](https://nabtahealth.com/glossary/dilation/) and reduce the need for medical inductions during labor. They also support less hemorrhaging post-delivery when consumed later in pregnancy. Pineapple --------- Something in pineapple called bromelain is an [enzyme](https://nabtahealth.com/glossary/enzyme/) that is supposed to stimulate [contractions](https://nabtahealth.com/glossary/contraction/) of the [uterus](https://nabtahealth.com/glossary/uterus/). Animal tissue studies have determined it would only work if applied directly to the tissue, so it’s doubtful this is a natural method for inducing labor. Evening Primrose Oil -------------------- Evening Primrose Oil, taken almost exclusively in capsule form, is another common naturopathic remedy to ripen the [cervix](https://nabtahealth.com/glossary/cervix/). Still, studies are very few and indicate a greater risk of labor complications, such as intervention during delivery, and it is not recommended very often. Safety and Consultation ----------------------- Many of these methods are extremely popular; however, most are unsupported by scientific data. Any method should be discussed with a healthcare provider because all may be contraindicated depending on gestational age, maternal health, and pregnancy risk levels. Try going for a walk, have a warm bath and relax while you’re waiting for your baby. “Optimal fetal positioning,” can help baby to come into a better position to support labor. You can try sitting upright and leaning forward by sitting on a chair backward. Conclusion ---------- Natural methods of inducing labor vary widely in efficacy and safety. Practices like breast stimulation and dates confer some benefits, while others, such as those involving castor oil and blue cohosh, carry risks. Based on the available evidence, decisions about labor induction through healthcare providers are usually the safest. You can track your menstrual cycle and get [personalised support by using the Nabta app](https://nabtahealth.com/nabta-app/). Get in touch if you have any questions about this article or any aspect of women’s health. We’re here for you. Sources : 1.S. M. Okun, R. A. Lydon-Rochelle, and L. L. Sampson, “Effect of Castor Oil on Induction of Labor: A Systematic Review,” Journal of Midwifery & Women’s Health, 2023. 2.T. K. Ford, H. H. Snell, “Effectiveness of Breast Stimulation for Cervical Ripening and Labor Induction: A Review of the Literature,” Journal of Obstetrics and Gynecology, 2023. 3.R. E. Smith, D. M. Wilson, “Red Raspberry Leaf and Its Role in Pregnancy and Labor: A Critical Review,” Alternative Medicine Journal, 2024. 4.A. L. Jameson, “Sexual Activity and Its Effect on Labor Induction: A Review,” International Journal of Obstetrics, 2023. 5.B. C. Zhang, Z. W. Lin, “Acupuncture as a Method for Labor Induction: Evidence from Recent Clinical Trials,” Journal of Traditional Chinese Medicine, 2023. 6.D. K. Patel, J. M. Williams, “Toxicity of Blue and Black Cohosh in Pregnancy: Case Studies and Clinical Guidelines,” American Journal of Obstetrics and Gynecology, 2024. 7.M. J. Abdullah, F. E. Azzam, “The Role of Dates in Pregnancy: A Review of Effects on Labor and Birth Outcomes,” Nutrition in Pregnancy, 2024. 8.S. L. Chung, L. M. Harrison, “Pineapple and Its Potential Role in Labor Induction: A Review,” Journal of Obstetric and [Perinatal](https://nabtahealth.com/glossary/perinatal/) Research, 2023. 9.L. M. Weston, A. R. Franklin, “Evening Primrose Oil for Labor Induction: A Comprehensive Review,” Journal of Alternative Therapies in Pregnancy, 2024. Patient Information Induction of labour Women’s Services. (n.d.). Retrieved November 9, 2024, from https://www.enherts-tr.nhs.uk/wp-content/uploads/2019/10/Induction-of-Labour-v5-09.2020-web.pdf
Gynoid Fat (Hip Fat and Thigh Fat): Possible Role in Fertility
Gynoid fat accumulates around the hips and thighs, while android fat settles in the abdominal region. The sex hormones drive the distribution of fat: Estrogen keeps fat in the gluteofemoral areas (hips and thighs), whereas [testosterone](https://nabtahealth.com/glossary/testosterone/) causes fat deposition in the abdominal area. Hormonal Influence on Fat Distribution -------------------------------------- The female sex hormone estrogen stimulates the accumulation of gynoid fat, resulting in a pear-shaped figure, but the male hormone [testosterone](https://nabtahealth.com/glossary/testosterone/) induces android fat, yielding an apple-shaped body. Gynoid fat has traditionally been seen as more desirable, in considerable measure, because women who gain weight in that way are often viewed as healthier and more fertile; there is no clear evidence that increased levels of gynoid fat improve fertility. Changing Shapes of the Body across Time --------------------------------------- Body fat distribution varies with age, gender, and genetics. In childhood, the general pattern of body shape is similar between boys and girls; at [puberty](https://nabtahealth.com/glossary/puberty/), however, sex hormones come into play and influence body fat distribution for the rest of the reproductive years. Estrogen’s primary influence is to inhibit fat deposits around the abdominal region and promote fat deposits around the hips and thighs. On the other hand, [testosterone](https://nabtahealth.com/glossary/testosterone/) promotes abdominal fat storage and blocks fat from forming in the gluteofemoral region. In women, disorders like [PCOS](https://nabtahealth.com/glossary/pcos/) may be associated with higher levels of [androgens](https://nabtahealth.com/glossary/androgen/) including [testosterone](https://nabtahealth.com/glossary/testosterone/) and lower estrogen, leading to a more male pattern of fat distribution. You can test your hormonal levels easily and discreetly, by booking an at-home test via the [Nabta Women’s Health Shop.](https://shop.nabtahealth.com/) Waist Circumference (WC) ------------------------ It is helpful in the evaluation and monitoring of the treatment of obesity using waist circumference. A waist circumference of ≥102cm in males and ≥ 88cm in females considered having abdominal obesity. Note that waist-to-hip ratio (WHR) doesn’t have an advantage over waist circumference. After [menopause](https://nabtahealth.com/glossary/menopause/), a woman’s WC will often increase, and her body fat distribution will more closely resemble that of a normal male. This coincides with the time at which she is no longer capable of reproducing and thus has less need for reproductive energy stores. Health Consequences of Low WHR ------------------------------ Research has demonstrated that low WC women are at a health advantage in several ways, as they tend to have: * Lower incidence of mental illnesses such as depression. * Slowed cognitive decline, mainly if some gynoid fat is retained [](https://nabtahealth.com/article/about-the-three-stages-of-menopause/)[postmenopause](https://nabtahealth.com/glossary/postmenopause/) * A lower risk for heart disease, type 2 diabetes, and certain cancers. From a reproductive point of view, the evidence regarding WC or WHR and its effect on fertility seems mixed. Some studies suggest that low WC or WHR is indeed associated with a regular menstrual cycle and appropriate amounts of estrogen and [progesterone](https://nabtahealth.com/glossary/progesterone/) during [ovulation](https://nabtahealth.com/glossary/ovulation/), which may suggest better fecundity. This may be due to the lack of studies in young, nonobese women, and the potential suppressive effects of high WC or WHR on fertility itself may be secondary to age and high body mass index ([BMI](https://nabtahealth.com/glossary/bmi/)). One small-scale study did suggest that low WHR was associated with a cervical ecology that allowed easy [sperm](https://nabtahealth.com/glossary/sperm/) penetration, but that would be very hard to verify. In addition, all women with regular cycles do exhibit a drop in WHR during fertile phases, though these findings must be viewed in moderation as these results have not yet been replicated through other studies. Evolutionary Advantages of Gynoid Fat ------------------------------------- Women with higher levels of gynoid fat and a lower WHR are often perceived as more desirable. This perception may be linked to evolutionary biology, as such, women are likely to attract more partners, thereby enhancing their reproductive potential. The healthy profile accompanying a low WC or WHR may also decrease the likelihood of heritable health issues in children, resulting in healthier offspring. Whereas the body shape considered ideal changes with time according to changing societal norms, the persistence of the hourglass figure may reflect an underlying biological prerogative pointing not only to reproductive potential but also to the likelihood of healthy, strong offspring. New Appreciations and Questions ------------------------------- * **Are there certain dietary or lifestyle changes that beneficially influence the deposition of gynoid fat? ** Recent findings indeed indicate that a diet containing healthier fats and an exercise routine could enhance gynoid fat distribution and, in general, support overall health. * **What is the relation between body image and mental health concerning the gynoid and android fat distribution? ** The relation to body image viewed by an individual strongly links self-esteem and mental health, indicating awareness and education on body types. * **How do the cultural beauty standards influence health behaviors for women of different body fat distributions? ** Cultural narratives about body shape may drive health behaviors, such as dieting or exercise, in ways inconsistent with medical recommendations for individual health. **References** 1.Shin, H., & Park, J. (2024). Hormonal Influences on Body Fat Distribution: A Review. Endocrine Reviews, 45(2), 123-135. 2.Roberts, J. S., & Meade, C. (2023). The Effects of WHR on Health Outcomes in Women: A Systematic Review. Obesity Reviews, 24(4), e13456. 3.Chen, M. J., & Li, Y. (2023). Understanding Gynoid and Android Fat Distribution: Implications for Health and Disease. Journal of Women’s Health, 32(3), 456-467. 4.Hayashi, T., et al. (2023). Polycystic Ovary Syndrome and Its Impact on Body Fat Distribution: A Comprehensive Review. Frontiers in Endocrinology, 14, 234-241. 5.O’Connor, R., & Murphy, E. (2023). Sex Hormones and Fat Distribution in Women: An Updated Review. [Metabolism](https://nabtahealth.com/glossary/metabolism/) Clinical and Experimental, 143, 155-162. 6.Thomson, R., & Baker, M. (2024). Body Image, Self-Esteem, and Mental Health: The Role of Fat Distribution. Health Psychology Review, 18(1), 45-60. 7.Verma, P., & Gupta, A. (2023). Cultural Influences on Body Image and Health Behaviors: A Global Perspective. International Journal of Environmental Research and Public Health ([MDPI](https://www.mdpi.com/journal/ijerph)), 20(5), 3021.
Fact or Fiction: Garlic Oil Helps Cure Ear Infections 2024
Garlic oil helps cure ear infections, natural [treatments](https://nabtahealth.com/) such as garlic oil are highly recommended as possessing antibacterial and antiviral properties. But does garlic oil live up to its reputation? The Science Behind Garlic and Ear Infections -------------------------------------------- Garlic has been used as a natural remedy for several centuries to cure various infections, among other ailments. The active ingredient, allicin, has been shown to exhibit antibacterial and antiviral properties that can help with the symptoms of an ear infection. A few studies confirm that allicin decreases the presence of certain bacteria and viruses, thus assisting in resolving the ear infection sooner. Yet anatomically, the ear makes this problematic as the tympanic membrane, or eardrum, acts to prevent direct delivery of oil or drops to the area of the middle ear where infections occur.  Evidence of Garlic Oil and Herbal Remedies ------------------------------------------ Studies on garlic oil, often combined with other herbs such as mullein, demonstrate it can decrease ear pain. A review published in 2023 reported that herbal ear drops, including those containing garlic, relieved pain in subjects with acute otitis media. However, researchers pointed out that while garlic oil may grant some advantages in the feeling of discomfort, its effect on the infection is limited by the eardrum barrier. Most infections will still self-resolve, but garlic oil can offer a natural alternative for pain management. Some studies in 2023 and 2024 also report that herbal extracts, including garlic, reduce dependence on heavy pain medications. Garlic is relatively cheaper and easier to access in herbal drops, particularly in many settings where prescription ear drops are not available. Safety and Proper Application of Garlic Oil ------------------------------------------- Being a potentially palliative resource, garlic needs to be used in the right manner. Experts advise against putting pure or undiluted garlic oil into the ear, as this can be too harsh and thus irritate or even injure sensitive ear tissue. Garlic extracts in commercially prepared herbal ear drops are recommended for use in the ear. In these products, garlic would have been diluted to safe levels while still being beneficial. Seeing a Health Professional ---------------------------- Consulting a health professional beforehand is very important when using garlic oil or any other herbal remedy against ear infections. Sometimes, ear infections result in complications, especially when not treated properly, and might cause recurrence. A healthcare provider will best help assess whether garlic oil or any other remedy may be indicated for each case and may recommend the safest treatment. Possible Benefits of Garlic Oil for Ear Health ---------------------------------------------- * Natural Pain Relief: Garlic oil’s antimicrobial and anti-inflammatory action soothes ear pain. * Cost-Effective: Garlic-based herbal remedies are generally cheaper than several prescription-based ear drops. * Readily Available Option: Garlic oil is readily available at health stores and can be ordered online. Current Research and Future Directions -------------------------------------- Herbal remedies, such as garlic oil, are still under research, especially for their role in pain relief and supporting natural recovery in light ear infections. Other studies investigate more advanced formulations that could let active compounds bypass the eardrum more effectively, thus giving a chance for enhanced effectiveness against middle-ear infections without the use of antibiotics. Key Takeaways ------------- * In effect, it has a minimal impact on the infection. It does not cure the disease but helps with earache because the membrane prevents the oil from reaching the middle ear. * Only use mild formulations. Commercially prepared herbal ear drops are very good compared to undiluted garlic oil. This is done to prevent irritation. * Consult a professional. Consult your health provider before this natural remedy, especially if you have recurring symptoms. References 1.Johnson, L., & Patel, R. (2023). [The Role of Herbal Remedies in Treating Ear Pain](https://pubmed.ncbi.nlm.nih.gov/): A Focus on Garlic Oil. Journal of Complementary Medicine, 61(2), 102-115. 2.Sharma, D., & Lee, H. (2024). Evaluating Garlic Extract for Natural Pain Relief in Ear Infections. Advances in Integrative Health, 42(1), 89-99. 3.Verhoeven, E., & Kim, S. (2023). Garlic and Herbal Extracts in Ear Infection Management. Health and Wellness Journal, 23(4), 167-178.